李立新 教授，博士生导师

高层次引进人才。Molecular Plant、New Phytologist、Plant Physiology, BMC plant biology、《遗传》、《植物生理学报》、《农业生物技术学报》、《中国草地学报》等杂志审稿专家.

电子邮箱：lixinli0515@nefu.edu.cn

地址：黑龙江省哈尔滨市香坊区和兴路26号

永利yl8886（新逸夫教学楼）

教育经历

1987.09-1991.06学士 东北师范大学生物系 生物学专业

2003.04-2005.03理学硕士 日本京都大学大学院理学部 分子细胞生物学专业

2005.04-2008.03理学博士 日本京都大学大学院理学部 分子细胞生物学专业

工作经历

2008.04-至今 永利yl8886官方网站 永利yl8886/东北盐碱植被恢复与重建教育部重点实验室 教授

2014.07-2016.05沙特国王科技大学 沙漠农业中心 访问学者

2012.11-2013.10 马里兰大学 农学院 访问学者

2009.08-2012.07 沙特国王科技大学 逆境基因组研究中心 博士后

1991.07-2000.10 哈尔滨市第一中学教师

研究领域

1.逆境条件下植物发育和胁迫应答机制；2.逆境条件下植物与微生物互作机制

讲授课程

本科生课程：《分子生物学》、《植物发育生物学》

研究生课程：《植物代谢与调控专题》

科研项目

(1)国家自然科学基金面上项目：盐碱胁迫下膜泡运输因子AtSYP71参与的细胞pH和离子稳态调控机制 （32170279），2022/01-2025/12，主持人。

(2)中央高校基本科研业务费专项资金创新团队项目：囊泡运输调控植物盐碱胁迫应答分子机制的研究（2572019CT03），2019/05-2022/04，主持人。

(3)国家自然科学基金面上项目：拟南芥MAG2和同源蛋白MAL缺失对生长素极性运输的影响（31570246），2016/01-2019/12，主持人。

(4)黑龙江省自然科学基金：储藏蛋白质运输相关AtSly1因子功能分析（C2016002），2016/01-2018/12，主持人。

(5)中央高校基本科研业务费专项资金创新团队资助：膜泡运输调控因子MIP2调控植物生长发育的机制初探（DL13EA04），2013.04-2016.03，主持人。

(6)国家自然科学基金面上项目：ER-SNARE在种子储藏蛋白质转运中的功能分析（30970223），2010/01-2013/12，主持人。

(7)中央高校基本科研业务费专项资金资助：膜泡运输中新型因子初探（DL09DA02），2010/01-2012/12，主持人。

(8)国家自然科学基金主任基金：植物种子细胞中储藏蛋白质转运的相关因子AtUfe1的功能分析（30840002），2009/01-2009/12，主持人。

代表性及近期学术论文

Wang Xiaoting, Wang Mingyu, Huang Yongshun, Zhu Peng, Qian Guangtao, Zhang Yiming, Liu Yuqi, Zhou Jingwen andLi Lixin*.Genome-Wide Identification and Analysis of Stress Response of Trehalose-6-Phosphate Synthase and Trehalose-6-Phosphate Phosphatase Genes in Quinoa. 2023. Int. J. Mol. Sci. doi: 10.3390/ijms24086950.

Qian G., Li X., Zhang H., Zhang H., Zhou J., Ma X., Sun W., Yang W., He R., Wahab A., Wan H.,Li Lixin*Metabolomics analysis reveals the accumulation patterns of flavonoids and phenolic acids in quinoa (Chenopodium quinoa Willd.) grains of different colors. 2023. Food Chemistry X. doi.org/10.1016/j.fochx.2023.100594

Qian G., Wang M., Wang X., Liu K., Li Y., Bu Y. andLi Lixin*Integrated Transcriptome and Metabolome Analysis of Rice Leaves Response to High Saline–Alkali Stress. 2023. Int. J. Mol. Sci., 24, 4062.

Wang M, Zhang H, Zhao X, Zhou J, Qin G, Liu Y, Kou X, Zhao Z, Wu T, Zhu JK, Feng X.,Li Lixin*SYNTAXIN OF PLANTS81 regulates root meristem activity and stem cell niche maintenance via ROS signaling. 2022. Plant Physiology 10.1093/plphys/kiac530

Ma X., Zhao X., Zhang H., Zhang Y., Sun S., Li Y., Long Z., Liu Y., Zhang X., Li R., Tan L., Jiang., Zhu J–K. andLi Lixin*MAG2 and MAL Regulate Vesicle Trafficking and Auxin Homeostasis With Functional Redundancy. Frontiers in Plant Science. 2022. 13:849532.

Li Guan, Shurui Yang, Shenglin Li, Yu Liu, Yuqi Liu, Yi Yang, Guochen Qin, Haihai Wang, Tao Wu, Zhigang Wang, Xianzhong Feng, Yongrui Wu, Zhu J–K., Li X.,Li Lixin*. AtSEC22 Regulates Cell Morphogenesis via Affecting Cytoskeleton Organization and Stabilities. Frontiers in Plant Science. 2021. 12:635732.

Zhao X., Guo X., Tang X., Zhang H., Wang M., Kong Y., Zhang X., Zhao Z., Lv M. andLi Lixin*. Misregulation of ER-Golgi Vesicle Transport Induces ER Stress and Affects Seed Vigor and Stress Response. 2018. Frontiers in Plant Science. 9:658.

Chunlei Zhang, Zipeng Yu, Mengyue Zhang, Xiaoxuan Li, Mingjing Wang,Lixin Li, Xugang Li, Zhaojun Ding, and Huiyu Tian. Serratia marcescens PLR enhances lateral root formation through supplying PLR-derived auxin and enhancing auxin biosynthesis in Arabidopsis. Journal of Experimental Botany (2021)

Tang LP, Yang Y, Wang H,Li Lixin, Liu L, Liu Y, Yuan J, Zhao XY, Palme K, Su YH, Li X. AtNSF regulates leaf serration by modulating intracellular trafficking of PIN1 in Arabidopsis thaliana. J Integr Plant Biol. 2020 Dec 2;63(4):737-55.

Butt H, Piatek A,Li Lixin, S N Reddy A, M Mahfouz M. Multiplex CRISPR Mutagenesis of the Serine/Arginine-Rich (SR) Gene Family in Rice. Genes (Basel). 2019 Aug 7;10(8):596.

Ling Y, Alshareef S, Butt H, Lozano-Juste J,Li Lixin, Galal AA, Moustafa A, Momin AA, Tashkandi M, Richardson DN, Fujii H, Arold S, Rodriguez PL, Duque P, Mahfouz MM. Pre-mRNA splicing repression triggers abiotic stress signaling in plants. Plant Journal. 2017 Jan;89(2):291-309.

Ali Z, Abul-faraj A,Li Lixin,Ghosh N, Piatek M, Mahjoub A, Aouida M, Piatek A, Baltes NJ, Voytas DF, Dinesh-Kumar S, Mahfouz MM. Efficient Virus-Mediated Genome Editing in Plants Using the CRISPR/Cas9 System. Molecular Plant. 2015 Aug;8(8):1288-91

Lixin Li,Shimada Tomoo, Takahashi H, Koumoto Y, Shirakawa M, Takagi J, Zhao X, Tu B, Jin H, Shen Z, Han B, Jia M, Kondo M, Nishimura M, Hara-Nishimura I. MAG2 and three MAG2 INTERACTING PROTEINs form an ER-localized complex to facilitate the storage protein transport in Arabidopsis thaliana. (2013) Plant Journal 76(5):781-791.

Li Lixin, Atef A, Piatek A, Ali Z, Piatek M, Aouida M, Sharakuu A, Mahjoub A, Wang G, Khan S, Fedoroff NV, Zhu JK, Mahfouz MM. Characterization and DNA-binding specificities of Ralstonia TAL-like effectors. Molecular Plant. 2013 Jul;6(4):1318-30.

Li Lixin, Piatek MJ, Atef A, Piatek A, Wibowo A, Fang X, Sabir JS, Zhu JK, Mahfouz MM. Rapid and highly efficient construction of TALE-based transcriptional regulators and nucleases for genome modification. Plant Mol Biol. 2012 Mar;78(4-5):407-16.

Mahfouz MM,Li Lixin. TALE nucleases and next generation GM crops. GM Crops. 2011 Apr-Jun;2(2):99-103.

Piatek A, Ali Z, Baazim H,Li Lixin, Abulfaraj A, Al-Shareef S, Aouida M, Mahfouz MM. RNA-guided transcriptional regulation in planta via synthetic dCas9-based transcription factors. Plant Biotechnol J. 2015 May;13(4):578-89.

Mahfouz MM,Li Lixin, Piatek M, Fang X, Mansour H, Bangarusamy DK, Zhu JK. Targeted transcriptional repression using a chimeric TALE-SRDX repressor protein. Plant Mol Biol. 2012 Feb;78(3):311-21.

Aouida M,Li Lixin, Mahjoub A, Alshareef S, Ali Z, Piatek A, Mahfouz MM. Transcription activator-like effector nucleases mediated metabolic engineering for enhanced fatty acids production in Saccharomyces cerevisiae. J Biosci Bioeng. 2015 Oct;120(4):364-71.

Mahfouz MM,Li Lixin,Shamimuzzaman M, Wibowo A, Fang X, Zhu JK. De novo-engineered transcription activator-like effector (TALE) hybrid nuclease with novel DNA binding specificity creates double-strand breaks. Proc Natl Acad Sci U S A. 2011 Feb 8;108(6):2623-8.

Li Lixin, Shimada, T., Takahashi, H., Ueda, H., Fukao, Y., Kondo, M., Nishimura M., Hara-Nishimura I. MAIGO2 is involved in exit of seed storage proteins from the endoplasmic reticulum in Arabidopsis thaliana. 2006 .Plant Cell 18, 3535–3547. doi: 10.1105/tpc. 106.046151

授权专利

国家专利1：一株简氏气单胞菌及其在提高植物抗逆性中的应用，专利号：ZL 2018 1 1318050.9

国家专利2：一株不动杆菌及其在提高植物抗逆性中的应用，专利号：ZL202111571225.9

国家专利3：一株希瓦氏菌及其在提高植物抗逆性中的应用， 专利号：ZL 201910401921.1